mitochondrial respiratory chain complex i v activity assay kit Search Results


mitochondrial respiratory complex i v activity assay kit  (Beijing Solarbio Science)
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Beijing Solarbio Science mitochondrial respiratory complex i v activity assay kit
Summary diagram. DEHP decreases the overall NAD + level of the placenta and reduces the NAD + level in the placental nucleus by participating in the regulation of NAD + regionalization. By destroying the placental <t>mitochondrial</t> structure, reducing the number of mitochondria, hindering the way of electron transfer in the <t>respiratory</t> chain, DEHP reduces ATP production. Under the combined action of NAD + and ATP depletion, inhibition of PARP1 activity leads to the accumulation of DNA damage and ultimately to the reduction of the placental trophoblast area. The partially damaging effects of DEHP on DNA and mitochondrial structures can be alleviated by moderate supplementation of NAD + precursor NAM.
Mitochondrial Respiratory Complex I V Activity Assay Kit, supplied by Beijing Solarbio Science, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Summary diagram. DEHP decreases the overall NAD + level of the placenta and reduces the NAD + level in the placental nucleus by participating in the regulation of NAD + regionalization. By destroying the placental mitochondrial structure, reducing the number of mitochondria, hindering the way of electron transfer in the respiratory chain, DEHP reduces ATP production. Under the combined action of NAD + and ATP depletion, inhibition of PARP1 activity leads to the accumulation of DNA damage and ultimately to the reduction of the placental trophoblast area. The partially damaging effects of DEHP on DNA and mitochondrial structures can be alleviated by moderate supplementation of NAD + precursor NAM.

Journal: Redox Biology

Article Title: Compartmentalized regulation of NAD + by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast

doi: 10.1016/j.redox.2022.102414

Figure Lengend Snippet: Summary diagram. DEHP decreases the overall NAD + level of the placenta and reduces the NAD + level in the placental nucleus by participating in the regulation of NAD + regionalization. By destroying the placental mitochondrial structure, reducing the number of mitochondria, hindering the way of electron transfer in the respiratory chain, DEHP reduces ATP production. Under the combined action of NAD + and ATP depletion, inhibition of PARP1 activity leads to the accumulation of DNA damage and ultimately to the reduction of the placental trophoblast area. The partially damaging effects of DEHP on DNA and mitochondrial structures can be alleviated by moderate supplementation of NAD + precursor NAM.

Article Snippet: The enzymatic activities of complex I (NADH dehydrogenase), complex II (succinate-coenzyme Q reductase), complex III (CoQ-cytochrome C reductase), complex IV (Cytochrome C oxidase) and complex V (F 1 F 0 -ATP synthase) were assayed using Mitochondrial Respiratory Complex I–V Activity Assay Kit (SolarBio, BC0515/BC3235/BC3245/BC0945/BC1445).

Techniques: Inhibition, Activity Assay